The collision involved two vehicles, a blue scooter and a black Mercedes Sprinter lorry, and happened at around 6.45am in Roughcote Lane, Caverswall.
The scooter rider, a 20-year-old man from Stoke-on-Trent, suffered serious leg injuries and was taken to the University Hospital of North Staffordshire where he remains for treatment.
Specially trained officers are carrying out an investigation at the scene and motorists are asked to avoid the area while the road remains closed.
A police spokesman said: "We'd like to thank those affected by the closure for their patience while we work to reopen the road.
If you witnessed the collision please contact us on 101, quoting incident number 110 of July 22."
West Midlands Ambulance Service was called to the junction of Leek Road and Roughcote Lane between Caverswall and Cellarhead shortly before 6.40am today.
A paramedic, a senior paramedic officer, a paramedic area support officer and a BASICS Emergency Doctor attended in rapid response vehicles. An ambulance crew also attended.
A West Midlands Ambulance Service spokesman said: “The motorcyclist, a man in his twenties, had leg fractures. His limbs were immobilised. Fluids and pain relief were intravenously administered at the scene and he was taken to the University Hospital of North Staffordshire.”