PREMIER Inn opened its doors in Leek on Monday with all 63 rooms booked.
The first guests, a family of four, arrived at 1.55pm.
Premier Inn's opening manager Victoria Smith said: "We had 180 guests on our first night. Tuesday is also booked and most rooms are full for the rest of the week. All rooms are also full at the weekend.
"We are really pleased. People have come from all over the country with many families going to Alton Towers.
"One couple were on the way to Scotland and stayed for a stop over on their journey on Monday night.
"The restaurant was very busy on Monday with visitors and also local people."
Operations manager of the hotel, Jenna Hardy, said the opening night and the first breakfast morning had gone very well.
She said: "It has been a very busy opening with lots of families staying at the hotel.
"We have received flowers and cards from several local businesses wishing us good luck.
"We have also raised £1,180 in the last two week for the Great Ormond Street Children's Hospital."
The new premises in Ashbourne Road were originally estimated to cost £4.5 million, however due to more work being required on the former Talbot pub the total investment made by Whitbread, who own the Premier Inn, has been £6.5 million.
The restaurant has 75 covers and is open to the public.
The new building has created 30 job opportunities which attracted more than 400 applications.